Fig. 3.

Age and stage transitions grouped by treatment.

The age and stage transition up to 15 years of age in patients undergoing different treatments are shown. The stage data (stages 1–5) for individual patients are shown in a staggered layout to avoid overlapping. Panel A: the late treatment group consisting of patients who were left untreated until stage 4 (n = 8); Panel B: the early ERT group consisting of patients who started receiving ERT at stage 2 (n = 6); and Panel C: the early HSCT group consisting of patients who underwent HSCT at stage 2 (n = 3). ERT, enzyme replacement therapy; HSCT, hematopoietic stem cell transplantation.