1.11. Analysis.

Comparison 1: Any O‐BCS versus S‐BCS, Outcome 11: Patient‐reported outcomes (BREAST‐Q)

Patient‐reported outcomes (BREAST‐Q)
Study	Intervention details (type ‐ n)	Intervention BREAST‐Q (n/100)	Control	Statistics	Conclusion
Acea‐Nebril 2017	VD ‐ 60	> 80 in all domains	‐	‐	No comparison
Di Micco 2017	VD ‐170	Median: psychological = 83; satisfaction with breast = 82 evolution = 73, sexual = 70	‐	‐	No comparison
PlaFarnos 2018	VD ‐ 70	Median (IQR): satisfaction with breast: 80 (0‐100); psychosocial well‐being: 76 (0‐100); sexual well being: 46 (26‐100); physical wellbeing: 81 (37‐100)	Median (IQR): satisfaction with breast: 68 (IQR 29‐100); psychosocial well‐being: 82 (0‐100); sexual well‐being: 57 (0‐100); physical well‐being: 75 (17‐100) P = 0.32/0.71/0.08/0.422	P value: 0.32/0.705/0.079/0.422	No significant difference (SD) in any domain
Rose 2020	Both ‐ 96	No. of patients above median score psychosocial: 2.15 (1.25‐3.69); physical: 0.83 (0.5‐1.39); satisfaction with breast: 0.95 (0.57‐1.59); sexual well‐being 1.42 (0.78‐2.58)	No. of patients above median score: psychosocial: 2.15 (1.25‐3.69); physical: 0.83 (0.5‐1.39); satisfaction with breast 0.95 (0.57‐1.59); sexual well‐being; 1.42 (0.78‐2.58)	Odds ratio psychosocial: 2.15 (1.25‐3.69); physical: 0.83 (0.5‐1.39); satisfaction with breast 0.95 (0.57‐1.59); sexual well‐being: 1.42 (0.78‐2.58)	Better psychosocial well‐being in O‐BCS. No SD in any other domain
Scheter 2019	VD ‐ 12	Mean score per domains: satisfaction with breast: 75.18; psychosocial well‐being: 76.09; sexual well‐being: 78	Satisfaction with breast: 39.64; psychosocial well‐being: 43.18; sexual well‐being: 41	0.001/0.025/0.021	O‐BCS better in satisfaction of breast, psychosocial wellbeing and sexual well‐being