Acea‐Nebril 2017.

Study characteristics
Methods	Retrospective single centre cohort Jan 2000 to June 2016 Complejo Hospitalario Universitario a Coruña, Spain 801 participants
Participants	Inclusion: women with invasive breast carcinoma/ductal carcinoma in situ (DCIS) undergoing breast conserving surgery Exclusion: patients who underwent mastectomy as the primary intervention, patients that did not give their consent to participate in the study
Interventions	Intervention: volume displacement ‐ reduction mammoplasty, (n = 170) Control: BCS ‐ wide local excision, (n = 631)
Outcomes	Primary outcomes (median 84 +/‐ 55.6 months): Local recurrence Disease‐free survival Overall survival Secondary outcomes: Re‐exicisions Complications PROMs (Breast‐Q) Time to adjuvant therapy Other outcomes: Operative time
Notes	Some overlap with Acea‐Nebril 2005 in patient group but different controls No funding/disclosures declared