DeLorenzi 2016 (2).

Study characteristics
Methods	Retrospective matched multicentre database review cohort 2000 ‐ 2008 European Institute of Oncology (IEO) Breast Cancer Institutional Database 579 participants
Participants	Inclusion: women with breast cancer with tumours larger than 2 cm (T2) undergoing OPS or mastectomy and reconstruction Exclusion: Patients who have received intraoperative radiotherapy with electrons (ELIOT) to the tumour bed only or as a boost Patients presenting with secondary tumours or local relapses, bilateral tumours, or those who have received neoadjuvant chemotherapy
Interventions	Intervention: volume displacement and replacement (analysed together): (n = 193) VR: glandular flaps (59.6 %), a fasciocutaneous flap (1.5 %) myocutaneous or muscular flap in 2 patients (1 %), implants (4.1 %) VD: mastopexy (18.1%), a round‐block approach (1.5 %), a superior pedicled reduction mammoplasty (2.1 %), an inferior pedicled reduction mammoplasty (7.7 %), other procedures were performed in the remaining 4 patients (4.1 %) Control: nipple areola‐sparing mastectomies (41.7 %), skin‐sparing mastectomies, (58.3 %) 91% immediate postmastectomy reconstruction (definitive silicone implants (273 patients), temporary expanders (74 patients), and muscular flaps (4 cases)), (n = 386)
Outcomes	Primaryoutcomes (median 88.8 months): Local recurrence Disease‐free survival Overall survival Secondaryoutcomes: No outcomes of interest Otheroutcomes: Distant recurrence
Notes	No disclosures/funding declared Different control to DeLorenzi 2016 (1)