TABLE 2.

The preclinic research of IPF over last decade

Year	Model	Animal	Cell source	Route	Outcome	References
2012	BLM induced	mice	ES	i.v.	Reduced inexpression of ECM and profibrotic genes.	58
2014	BLM induced	mice	BM‐MSC (STC1 plasmid)	i.t.	STC1 plasmid transfected to MSCs/STC1 inhalation as promising treatments for IPF	58
2015	BLM induced	mice	BM‐MSC	i.v.	Exhibited fibrosis (MMP‐2) activity, oxidative stress, apoptosis.	151
2016	BLM/orally induced	mice	BM‐MSC	i.v.	Immunomodulation and anti‐fibrotic effect at IPF early stage.	88
2018	BLM induced	mice	BM‐MSC with G‐CSF	i.v.	Promoted BM‐MSCs homing via upregulating CXCR4, increasing antifibrotic effects of BM‐MSCs.	90
2018	BLM induced	mice	BM‐MSC	i.t.	BM‐MSCs from IPF patients are senescent, inducing inflammation and senescence in the neighboring cells	91