TABLE 5.

The preclinic research of Asthma over last decade

Year	Model	Animal	Cell source	Route	Outcome	References
2010	ragweed induced	mice	BM‐MSC	i.v.	BM MSC suppressed Th2‐driven allergic responses by TFG‐ β production	84
2012	ovalbumin induced	mice	h iPSC vs. BM‐MSC	i.v.	iPSC‐MSC owned same therapeutic effect as BM MSC	265
2015	house dust mite induced	mice	BM‐MSC	i.v.	Reduced eosinophilia, Th2 response and activated dendritic cells	266
2015	ovalbumin induced	mice	BM‐MSC	i.v.	Reduced lymphocytes and eosinophils attraction, suppressed lung dendritic cell maturation and Th2 responses	267
2016	ovalbumin induced	mice	BM‐MSC	i.v.	Reduced neutrophils and eosinophils recruitment, goblet cell hyperplasia and lung fibrosis	268
2016	house dust mite induced	mice	BM‐MSC	i.v.	Expressed high levels of COXZ (MSCs), IL‐10 and TGF‐β (M2 macrophages) and low level of IL‐6	269
2017	house dust mite induced	mice	BM‐MSC	i.t.	Reduced inflammation, remodeling, and improved lung functions	135
2017	ovalbumin induced	mice	hUCB‐MSC	i.v.	Reduced allergic inflammation which mediated by regulatory I cells	270
2018	ovalbumin induced	mice	BM‐MSC vs. AT‐MSC	i.t.	Therapeutic efficiency only after BM‐MSC treated	136
2018	ovalbumin induced	rat	hPD‐MSC	i.v.	Shifted from Notch‐1, ‐2 and jagged‐1 to Notch‐3, ‐4 and delta‐like ligand‐4 signaling	271
2018	ovalbumin induced	mice	mASC‐	i.t.	Alleviated airway inflammation, improved airway remodeling, and relieved airway hyper‐responsiveness with the restoration of Th1/Th2 cell balance	16
2019	ovalbumin induced	mice	BM‐MSC	i.v.	Simvastatin and BMSCs affected serum IgE, lung IL‐13 and TGF‐β levels more than BMSC. Simvastatin increased BMSCs migration into the lung tissue	272
2019	Th2‐mediated inflammation induced	rats	rBM‐MSC	i.t.	Ameliorated pathological changes presumably by targeting ICAM‐1 and VCAM‐1	13