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. 2021 Oct 14;9(10):e30404. doi: 10.2196/30404

Table 2.

Descriptive statistics of the mobile apps (N=64) containing prenatal genetic testing information.

Characteristic and category Value, n (%)
Type of developer

App created by commercial companies 49 (77)

App created by hospitals 11 (17)

App created by non-governmental organizations 3 (5)

Apps created by the government (ie, California Department of Public Health) 1 (2)
Operating system

Android only 15 (23)

iOS only 11 (17)

Android and iOS 38 (59)
Type of prenatal genetic tests mentioned

Amniocentesis 49 (77)

CVSa 49 (77)

First trimester screening (NTb screening) 46 (72)

Triple/quad screening 44 (69)

Cell-free DNA testing or NIPTc 35 (55)

Anatomy ultrasound 26 (41)

Cordocentesis 10 (16)

Expanded carrier screening 8 (13)

First trimester screening (blood test) 8 (13)

Genetic screening (prenatal) in general 7 (11)

Carrier screening 6 (9)
Prenatal genetic test procedures mentioned

Amniocentesis 37 (58)

CVS 36 (56)

First trimester screening (NT screening) 34 (53)

Cell-free DNA testing or NIPT 25 (39)

Triple/quad screening 17 (27)

Cordocentesis 9 (14)

Anatomy ultrasound 5 (8)

Carrier screening 4 (6)

First trimester screening (blood test) 3 (5)

Expanded carrier screening 1 (2)

Not reported 17 (27)
Timing of prenatal genetic tests mentioned

CVS 45 (70)

Amniocentesis 44 (69)

First trimester screening (NT screening) 40 (63)

Triple/quad screening 38 (59)

Cell-free DNA testing or NIPT 31 (48)

Anatomy ultrasound 23 (36)

Cordocentesis 9 (14)

First trimester screening (blood test) 8 (13)

Carrier screening 3 (5)

Expanded carrier screening 1 (2)

Genetic screening (prenatal) in general 1 (2)

Not reported 5 (8)
Reliability or accuracy of prenatal genetic tests mentioned

Cell-free DNA testing or NIPT 23 (36)

Amniocentesis 21 (33)

First trimester screening (NT screening) 13 (20)

CVS 12 (19)

Triple/quad screening 12 (19)

Cordocentesis 2 (3)

Carrier screening 1 (2)

Expanded carrier screening 1 (2)

First trimester screening (blood test) 1 (2)

Anatomy ultrasound 1 (2)

Not reported 33 (52)
Interpretation of potential results of prenatal genetic tests

Triple/quad screening 19 (30)

Cell-free DNA testing or NIPT 13 (20)

Amniocentesis 12 (19)

First trimester screening (NT screening) 9 (14)

Expanded carrier screening 8 (13)

CVS 8 (13)

Carrier screening 3 (5)

Genetic screening (prenatal) in general 1 (2)

Not reported 36 (56)
Specific disorder(s) mentioned

Trisomy 21 (Down syndrome) 53 (83)

Trisomy 18 (Edward syndrome) 33 (52)

Cystic fibrosis 29 (45)

Trisomy 13 (Patau syndrome) 18 (28)

Sickle cell anemia 14 (22)

Tay-Sachs disease 11 (17)

Spinal muscular atrophy 8 (13)

Neural tube defect (general) 3 (5)


Spina bifida 15 (23)



Anencephaly 6 (9)


Thalassemia 3 (5)

Fragile X syndrome 2 (3)

Huntington disease 2 (3)

Muscular dystrophy 2 (3)

Klinefelter syndrome 1 (2)

Prader-Willi syndrome 1 (2)

Trisomy 16 1 (2)

Turner syndrome 1 (2)

Not reported 9 (14)
Citation for prenatal genetic testing information

No 48 (75)



Yes (reliable source) 14 (22)



Yes (non-reliable source) 2 (3)


Costd: $0 64 (100)


Customer ratinge, mean (SD); range 4.5 (0.6); 2.0-5.0


aCVS: chorionic villus sampling.

bNT: nuchal translucency.

cNIPT: noninvasive prenatal testing.

dFive apps had an optional upgrade fee but upgrading did not affect the amount of prenatal genetic testing information available to the user.

eOnly 52 of the 64 apps (81.3%) had customer ratings.