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Plasma angiogenic biomarkers before and on treatment. Angiopoietin-2 (ANG2) levels (A), angiopoietin-1 (ANG1) (B), soluble vascular endothelial growth factor receptor 3 (sVEGFR3) (C), and ratio of ANG2/ANG1 (D) were measured by multiplex in plasma from age and sec-matched controls (open circles) and the KLA patient at diagnosis (black circles) and over the treatment course as indicated along x-axis. Normal reference ranges are indicated by gray shading
