Table 3.
Descriptive characteristics of patients with immunotherapy for post-transplant hepatocellular carcinoma recurrence
|
|
All
|
Nivolumab
|
Pembrolizumab
|
P
value
|
| Total (%) | 19 | 14 (74) | 5 (26) | |
| Rejection (%) | 6 (32) | 5 (36) | 1 (20) | 0.52 |
| Early mortality (%) | 5 (26) | 5 (36) | 0 (0) | 0.12 |
| Line of systemic therapy | 2 (1-3) | 3 (2-4) | 2 (1-2) | 0.03 |
| Tumour PD-L1 positivity (%) | 3/7 (43) | 3/7 (43) | 0/0 (-) | |
| Best treatment response (%) | ||||
| Complete response | 2 (11) | 0 (0) | 2 (40) | 0.03 |
| Partial response | 0 (0) | 0 (0) | 0 (0) | 0.64 |
| Stable disease | 2 (11) | 1 (7) | 1 (20) | 0.58 |
| Progressive disease | 8 (42) | 7 (50) | 1 (20) | 0.03 |
| Progression-free survival | 2.5 ± 1.0 | 1.3 ± 1.1 | 12.4 | 0.004 |
| Overall survival | 7.3 ± 2.7 | 4.0 ± 3.4 | 19.2 | 0.006 |
PD-L1: Programmed death ligand-1.