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Reduction of apoptosis in cardiomyocytes of diabetic mice (db/db) with rapamycin treatment during reoxygenation (SI/RO). Cardiomyocytes (isolated from C57 and db/db mice) were subjected to SI/RO. During RO (18 h), cardiomyocytes were treated with rapamycin (RAPA, 100 nM) or DMSO (solvent of RAPA). Cardiomyocyte apoptosis was determined by TUNEL assay following 40 min SI and 18 h RO
