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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Toxicology. 2021 Aug 28;462:152921. doi: 10.1016/j.tox.2021.152921

Figure 7. Hypothesized mechanisms of PFAS partitioning to pups.

Figure 7.

PFOA levels in pup serum and liver were increased with HFD compared PFOA treatment alone, it is hypothesized that this may be controlled by upregulation of membrane transporters in A) placental syncytiotrophoblasts and/or B) mammary epithelial cells. PFOS levels in pup serum and liver in the SD group were lower in the PFAS mixture. PFOA may act as an inhibitor of membrane transporter in C) placental syncytiotrophoblasts and/or D) mammary epithelial cells and reduce PFOS partitioning to pups in the mixture.