Scheme 1.

Results of HTE Library Survey of 222 Different Products Utilizing ChemBeads and three different cross-electrophile coupling catalysts (L1, L10, L13). Green denotes molecular ion for product observed by LC-MS at 10 µmol scale and verified by isolation at 100 µmol scale; Yellow denotes molecular ion observed at 10 µmol scale, but isolation at 100 µmol scale did not provide >95% pure product; Red denotes no ion observed. Yields reported are isolated yields after isolation by mass-directed HPLC. Ligands only noted if a large difference was noted or if the product was isolated. No noted ligand means that all three ligands worked well. See Supporting Information for experimental details.