Table 3.
Odds ratios and 95% confidence intervals for TGCT associated with domestic use of pesticides during early periods of development, overall and according to histological subtypes, case-control study, N = 578, France, 2015–2018
| Total | Controls A + B | All TGCT cases | Non-Seminomas | Seminomas | P-HETb | ||||
|---|---|---|---|---|---|---|---|---|---|
| (N = 578) | (N = 274) | (N = 304) | (N = 132) | (N = 144) | |||||
| n (%) | n (%) | n (%) | ORa (95% CI) | n (%) | ORa (95% CI) | n (%) | ORa (95% CI) | ||
| Domestic use of insecticides | 0.12 | ||||||||
| No | 129 (22.3) | 62 (22.6) | 67 (22) | 1.00 | 28 (21.2) | 1.00 | 34 (23.6) | 1.00 | |
| Yes | 447 (77.3) | 211 (77.0) | 236 (77.6) | 1.27 (0.80, 2.01) | 104 (78.8) | 1.78 (0.91, 3.48) | 109 (75.7) | 0.89 (0.50, 1.59) | |
| Missing | 2 (0.3) | 1 (0.4) | 1 (0.3) | – | 0 (0.0) | – | 1 (0.7) | – | |
| Domestic use of fungicides | 0.08 | ||||||||
| No | 478 (82.7) | 234 (85.4) | 244 (80.3) | 1.00 | 100 (75.8) | 1.00 | 123 (85.4) | 1.00 | |
| Yes | 92 (15.9) | 37 (13.5) | 55 (18.1) | 1.73 (1.04, 2.87) | 31 (23.5) | 2.44 (1.26, 4.74) | 18 (12.5) | 1.04 (0.52, 2.07) | |
| Missing | 8 (1.4) | 3 (1.1) | 5 (1.6) | – | 1 (0.8) | – | 3 (2.1) | – | |
| Domestic use of herbicides | 0.17 | ||||||||
| No | 508 (87.9) | 242 (88.3) | 266 (87.5) | 1.00 | 111 (84.1) | 1.00 | 129 (89.6) | 1.00 | |
| Yes | 70 (12.1) | 32 (11.7) | 38 (12.5) | 1.15 (0.67, 2.00) | 21 (15.9) | 1.64 (0.83, 3.27) | 15 (10.4) | 0.80 (0.37, 1.71) | |
| Missing | 0 (0.0) | 0 (0) | 0 (0.0) | – | 0 (0.0) | – | 0 (0.0) | – | |
| Domestic use of any pesticides | 0.18 | ||||||||
| No | 119 (20.6) | 57 (20.8) | 62 (20.4) | 1.00 | 25 (18.9) | 1.00 | 32 (22.2) | 1.00 | |
| Yes | 456 (78.9) | 215 (78.5) | 241 (79.3) | 1.18 (0.74, 1.88) | 107 (81.1) | 1.56 (0.79, 3.06) | 111 (77.1) | 0.84 (0.47, 1.51) | |
| Missing | 3 (0.5) | 2 (0.7 | 1 (0.3) | – | 0 (0.0) | – | 1 (0.7) | – | |
OR odds ratios, CI confidence intervals
a Estimates obtained comparing TGCT cases to group A and group B controls combined. Analysis was restricted to subjects with no missing data for the exposure variable (0.2 to 1.4% excluded)
b P-value for heterogeneity derived from the Likelihood Ratio Test, comparing seminoma versus non-seminoma tumours