Table 3.

Interaction of XPC polymorphisms and smoking on development of oral cancer

XPC A > C, C > T and D/I genotypes
XPC genotypes	Oral cancer	Control	p value	Odds ratio	95% CI
No habit
D/I polymorphism
DD	15 (58%)	99 (45%)	Ref	1	1
DI + II	11 (42%)	123 (55%)	0.28	0.59	0.25–1.34
C/T polymorphism
CC	09 (35%)	51 (23%)	Ref	1	1
CT + TT	17 (65%)	169 (77%)	0.29	0.57	0.23–1.35
A/C polymorphism
AA	13 (54%)	104 (46%)	Ref	1	1
AC + CC	11(46%)	120 (54%)	0.61	0.73	0.31–1.70
Smoking
D/I polymorphism
DD	25 (57%)	39 (50%)	Ref	1	1
DI + II	19 (43%)	39 (50%)	0.59	0.76	0.36–1.59
C/T polymorphism
CC	13 (28%)	18 (23%)	Ref	1	1
CT + TT	33 (72%)	59 (77%)	0.69	0.77	0.33–1.77
A/C polymorphism
AA	10 (23%)	37 (47%)	Ref	1	1
AC + CC	33 (77%)	41 (53%)	0.01*	2.97	1.29–6.86

*Significant association is considered when p value is less than 0.05 and both bondries of 95% confidence interval are more than 1 in risk association and less than 1 in protective association