Table 3.

Change in estimated glomerular filtration rate in relation to baseline growth differentiation factor-15 (GDF-15)

	No. of subjects	B (95% CI) a	p
GDF-15 Q1	790	Reference	–
GDF-15 Q2	763	−1.04 (−2.30, 0.22)	0.10
GDF-15 Q3	646	−1.67 (−3.01, −0.32)	0.02
GDF-15 Q4	545	−2.42 (− 3.91, − 0.94)	< 0.01
Per 1 standard deviation change in GDF-15	2744	− 0.97 (− 1.49, − 0.45)	< 0.001

CI confidence interval, eGFR estimated glomerular filtration rate according to the combined Chronic Kidney Disease Epidemiology Collaboration creatinine and cystatin C equation

^a Adjusted for waist circumference, smoking, high alcohol consumption, systolic blood pressure, low-density lipoprotein cholesterol, C-reactive protein level, diabetes, cardiovascular disease, anti-hypertensive drug medication, and baseline estimated glomerular filtration rate