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. 2021 Oct 28;14:142. doi: 10.1186/s13048-021-00904-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Expression of genes related to steroidogenesis. GCs were cultured for 7 days to form a monolayer. On day 8, a monolayer of GCs was cocultured with COCs either with or without the supplementation with the high level of NEFAs during in vitro maturation. The transcript abundance of different genes related to estradiol and progesterone was determined after IVM. The expressions of STAR, HSD3B1, and CYP19A3 was not affected by the high level of NEFAs. NC is the control group, and FA is the group exposed to the elevated level of NEFA. STAR: Steroidogenic Acute Regulatory Protein; CYP11A1: Cytochrome P450 Family 11 Subfamily A Member 1; HSD3B1: Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1; CYP19A3: Cytochrome P450 Family 19 Subfamily A 3