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. 2021 Oct 28;14:142. doi: 10.1186/s13048-021-00904-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Bubble chart of potential signaling pathways generated by KEGG. Pathway analysis was performed to associate the unique DEGs with pathways using the KEGG database. The size and color of each bubble represent the number of DEGs in the pathway and the P-value, respectively. Fold enrichment was calculated as the ratio of genes (the number of genes from the dataset enriched in the pathway in question divided by all the genes from the dataset) divided by the ratio of background (the number of annotated genes from the background enriched in the pathway in question divided by all annotated genes from background)