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Location of cancer cluster regions in BRCA1 and BRCA2 for breast and ovarian cancer [58]
| BRCA 1 | Exon | Domain | BRCA 2 | Exon | Domain | ||
|---|---|---|---|---|---|---|---|
| Breast Cancer Cluster Region | c.179 to c.505 | 5 | RING | c.1 to c.596 | 1 | – | |
| c.4328 to c.4945 | 13 | Serine Cluster | c.772 to c.1806 | 3 | – | ||
| c.5261 to c.5563 | 19 | BRCT | c.7394 to c.8904 | 14 | DNA binding | ||
| Ovarian Cancer Cluster Region | c.1380 to c.4062 | 11 | Part of region contains Serine Cluster | c.3249 to c.5681 | 11 | BRC | |
| c.6645 to c.7471 | 11 | BRC |
