Table 2.
Baseline characteristics in the unmatched and matched cohorts for AAS in BAV versus TAV
| Characteristic | Unmatched cohort | P value | Matched cohort | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BAV (n = 880) | TAV (n = 81,005) | BAV (n = 870) | TAV (n = 870) | ||||||
| Age | 53.07 ± 14.2 | 65.19 ± 15.3 | < 0.001 | 53.29 ± 14.1 | 54.57 ± 15.7 | ||||
| Female sex | 175 | 19.9% | 33,144 | 40.9% | < 0.001 | 175 | 20.1% | 125 | 14.4% |
| Race | |||||||||
| White | 655.001 | 74.4% | 46,869 | 57.9% | < 0.001 | 645 | 74.1% | 655 | 75.3% |
| Black | 55 | 6.2% | 17,730 | 21.9% | 55 | 6.3% | 45 | 5.2% | |
| Hispanic | 50 | 5.7% | 5060 | 6.2% | 50 | 5.7% | 60 | 6.9% | |
| Asian/Pacific Islander | NR | 1.1% | 2920 | 3.6% | NR | 1.1% | NR | 1.1% | |
| Native American | NR | 1.1% | 220 | 0.3% | NR | 1.1% | – | – | |
| Other races | 25 | 2.8% | 2849 | 3.5% | 25 | 2.9% | 15 | 1.7% | |
| Coagulopathy | 280 | 31.8% | 14,715 | 18.2% | < 0.001 | 275 | 31.6% | 285 | 32.8% |
| Obesity | 115 | 13.1% | 11,739 | 14.5% | < 0.001 | 115 | 13.2% | 90 | 10.3% |
| Fluid and electrolyte disorders | 400 | 45.5% | 32,329 | 39.9% | 0.124 | 395 | 45.4% | 365 | 42.0% |
| Hypertension | 540 | 61.4% | 64,395 | 79.5% | < 0.001 | 535 | 61.5% | 545 | 62.6% |
| Hypothyroidism | 40 | 4.5% | 8754 | 10.8% | 0.007 | 40 | 4.6% | 50 | 5.7% |
| Chronic kidney disease | 95 | 10.8% | 16,670 | 20.6% | 0.002 | 90 | 10.3% | 105 | 12.1% |
| Chronic liver disease | 10 | 1.1% | 2045 | 2.5% | 0.238 | NR | 1.1% | NR | 1.1% |
| Chronic lung disease | 90 | 10.2% | 18,630 | 23.0% | < 0.001 | 90 | 10.3% | 130 | 14.9% |
| Coronary artery disease | 175 | 19.9% | 23,549 | 29.1% | 0.006 | 170 | 19.5% | 175 | 20.1% |
| Diabetes mellitus | 75 | 8.5% | 13,264 | 16.4% | 0.005 | 75 | 8.6% | 75 | 8.6% |
| Anemia | 125 | 14.2% | 16,860 | 20.8% | 0.030 | 125 | 14.4% | 195 | 22.4% |
| Hx of ICD | – | – | 1135 | 1.4% | 0.113 | – | – | NR | 1.1% |
| Hx of cardiac pacemaker | 15 | 1.7% | 2010 | 2.5% | 0.508 | 15 | 1.7% | 15 | 1.7% |
| Prior PCI | 20 | 2.3% | 3920 | 4.8% | 0.113 | 20 | 2.3% | 25 | 2.9% |
| Prior CABG | NR | 0.6% | 5119 | 6.3% | 0.002 | NR | 0.6% | NR | 1.1% |
| Prior stroke | NR | 0.6% | 6199 | 7.7% | < 0.001 | NR | 0.6% | NR | 1.1% |
| Hx of smoking | 210 | 23.9% | 18,644 | 23.0% | 0.792 | 210 | 24.1% | 210 | 24.1% |
| Hx of heat failure | 20 | 2.3% | 8790 | 10.9% | < 0.001 | 20 | 2.3% | 45 | 5.2% |
| Pulmonary circulation disease | 20 | 2.3% | 2170 | 2.7% | 0.740 | 15 | 1.7% | 35 | 4.0% |
| Peripheral vascular disease | 320 | 36.4% | 37,029 | 45.7% | 0.013 | 315 | 36.2% | 335 | 38.5% |
| Hospital bed-size | |||||||||
| Small-sized | 50 | 5.7% | 6314 | 7.8% | 0.298 | 50 | 5.7% | 65 | 7.5% |
| Medium-sized | 155 | 17.6% | 16,684 | 20.6% | 155 | 17.8% | 165 | 19.0% | |
| Large-sized | 675 | 76.7% | 58,005 | 71.6% | 665 | 76.4% | 640 | 73.6% | |
| Hospital region | |||||||||
| Northeast | 210 | 23.9% | 15,300 | 18.9% | 0.137 | 210 | 24.1% | 225 | 25.9% |
| Midwest or North Central | 210 | 23.9% | 18,909 | 23.3% | 205 | 23.6% | 225 | 25.9% | |
| South | 250 | 28.4% | 29,539 | 36.5% | 250 | 28.7% | 230 | 26.4% | |
| West | 210 | 23.9% | 17,255 | 21.3% | 205 | 23.6% | 190 | 21.8% | |
| Hospital teaching status | |||||||||
| Rural | – | – | 2435 | 3.0% | < 0.001 | – | – | NR | 0.6% |
| Urban non-teaching | 110 | 12.5% | 14,594 | 18.0% | 110 | 12.6% | 140 | 16.1% | |
| Urban teaching | 770 | 87.5% | 63,974 | 79.0% | 760.001 | 87.4% | 725 | 83.3% | |
| Valvular disease | 175 | 9.4% | 7605 | 19.9% | < 0.001 | 165 | 19.0% | 205 | 23.6% |
PCI percutaneous coronary intervention, CABG coronary artery bypass grafting, ICD implantable cardiac defibrillator, Hx history; NR Not reportable per HCUP regulations