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. 2021 Oct 28;7:16. doi: 10.1186/s42234-021-00077-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — How can spinal cord stimulation lead to functional improvements in SCI? a SCS provides a prosthetic effect that enables activation of previously paralyzed muscles. b The prosthetic effect of SCS enables prolonged activation of paralyzed muscles in a physical therapy setting. c Long-term practice with activity-based training and SCS results in increases clinical measures of function in chronic SCI. Modified with permission from (Wagner et al. 2018)