Table 2.
Estimated glomerular filtration rate by HIV and antiretroviral therapy (ART) status
| HIV-uninfected (n = 654)1 |
HIV-infected ART naive (n = 955)1 |
p* value2 | HIV-infected on ART (n = 333)1 |
p* value3 | p* value4 | |
|---|---|---|---|---|---|---|
| eGFR (ml/min/1.73m2), mean (SD)5 | 111.2 (37.6) | 109.7 (35.3) | 0.06 | 129.5 (59.6) | < 0.001 | < 0.001 |
| Impaired renal function (eGFR< 60 mL/min/1.73m2), n (%) | 37 (5.7) | 77 (8.1) | 0.045 | 21 (6.3) | 0.20 | 0.76 |
| eGFR categories (in eGFR > 135 mL/min/1.73m2) | ||||||
| High normal (> 135)6 | 173 (26.5) | 257 (26.9) | 0.73 | 141 (42.3) | < 0.001 | < 0.001 |
| Normal (90–135) | 300 (45.9) | 417 (43.7) | 127 (38.1) | |||
| Mildly decreased (60–89) | 144 (22.0) | 204 (21.4) | 44 (13.2) | |||
| Mildly to moderately decreased (45–59) | 26 (4.0) | 50 (5.2) | 5 (1.5) | |||
| Moderately to severely decreased (30–44) | 8 (1.2) | 17 (1.8) | 10 (3.0) | |||
| Severely decreased (15–29) | 3 (0.5) | 7 (0.7) | 3 (0.9) | |||
| Kidney failure (< 15) | 0 (0.0) | 3 (0.3) | 3 (0.9) | |||
1Missing eGFR results: One in HIV-uninfected, one in ART-naive HIV-infected and three in HIV-infected on ART; 2Comparing ART-naive HIV-infected with HIV-uninfected group; 3Comparing HIV-infected on ART with ART-naive HIV-infected group; 4Comparing HIV-infected on ART with HIV-uninfected group; 5Standard deviation; 6Renal hyper filtration
*Adjusted for age, sex and fat-free mass