Table 5.
GWAS dataset | MR-Egger intercept | MR-PRESSO global test | Heterogeneity test from IVW | ||||
---|---|---|---|---|---|---|---|
Intercept | 8. 95% CI | P value | P value | I2 | 95% CI | Q statistics P value | |
IGAP | −0.013 | [−0.030, 0.003] | 0.116 | 0.5045 | 0.0% | [0.0%, 55.6%] | 0.5357 |
Maternal AD group from UK Biobank | 0.004 | [−0.006, 0.014] | 0.416 | 0.4305 | 0.0% | [0.0%, 39.0%] | 0.7701 |
Paternal AD group from UK Biobank | 0.004 | [−0.013, 0.021] | 0.616 | 0.297 | 32.3% | [0.0%, 66.7%] | 0.1409 |
UK Biobank AD proxy | 0.004 | [−0.005, 0.013] | 0.354 | 0.1785 | 17.7% | [0.0%, 57.9%] | 0.2748 |
Cognitive performance | 0.002 | [−0.003, 0.008] | 0.404 | 0.0035 | 66.7% | [37.2% 82.4%] | 8E-04 |
The significance threshold is P < 0.05