Fig. 5.

Schematic representation of the delivery and US-assisted implosion of Qc@SNPs-MB to open the BBB and increase the permeability of Qc@SNPs into CNS, where the QC@SNPs are then internalized into neurons to relieve oxidative stress, inflammation, Ca²⁺ dyshomeostasis and cell apoptosis. (b) In vivo fluorescence images of mice subjected to Qc@SNPs, Qc@SNPs-MB and Qc@SNPs + US. (c) Water maze test of WT and AD mice subjected to different formulations. (d) Schematic diagram of piezoelectric dissociation of Aβ aggregates on the surface of BiOCl nanosheets under US irradiation. (e) H₂O₂ production rate under different BiOCl concentrations and US powers. (f) Cell viability of N2a cells incubated with Aβ aggregates after subjecting to different treatment groups without/with BiOCl and US sonication. Reprinted from [85], [89] with permission from the Royal Society of Chemistry and Elsevier.