Fig. 6.

(a) Schematic diagram showing the synthesis and functionalities of iodide-doped Ag/AuNR for RONS detection. (b and c) PA images expressing the oxidative stress in murine models using Zymosan as the ROS generating agent. The PA signal is acquired at 680 nm at different time intervals. Schematic illustration of high-resolution ultrafast Doppler imaging of the brain vasculature of mice through (d) bilateral thinned-skull window (TSW), (e) intact skull (IS), and (f) unilateral thinned-skull window (with both TSW and IS). Mice brain vascular images under (g) bilateral TSW without MBs (h) IS without/with MBs and (i) unilateral TSW without/with MBs. Yellow boxes in g-h indicate the fUS signal in the choroid plexus of the lateral ventricle, allowing the correct setup of the US probe. All scale bar = 2 mm. Reprinted from [90], [92] with permission from the Royal Society of Chemistry and Elsevier. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)