Table 3.
Results of the longitudinal mixed-effects analyses of baseline hyperuricemia status with cognitive function; the Rancho Bernardo Study(n=1,634)
Women | Men | P for sex | ||||
---|---|---|---|---|---|---|
Model | β (S.E) | p-value | β (S.E) | p-value | interaction | |
MMSE | ||||||
Hyperuricemia | Min | 0.25 (0.19) | .19 | −0.70 (0.27) | .009 b | .001 |
Time × Hyperuricemia | Min | −0.01 (0.03) | .71 | 0.06 (0.04) | .14 | .07 |
Hyperuricemia | Full | 0.16 (0.20) | .43 | −0.84 (0.27) | .002 b | .001 |
Time × Hyperuricemia | Full | −0.01 (0.03) | .62 | 0.05 (0.04) | .15 | .07 |
Trails B | ||||||
Hyperuricemia | Min | 5.57 (5.56) | .32 | 1.98 (6.16) | .75 | .57 |
Time × Hyperuricemia | Min | −0.02 (0.92) | .98 | 0.83 (0.79) | .30 | .44 |
Hyperuricemia | Full | 2.50 (6.00) | .67 | 7.35 (6.18) | .24 | .85 |
Time × Hyperuricemia | Full | 0.15 (0.92) | .87 | 0.89 (0.79) | .26 | .49 |
Category fluency | ||||||
Hyperuricemia | Min | −0.26 (0.42) | .54 | −0.32 (0.59) | .59 | .89 |
Time × Hyperuricemia | Min | 0.03 (0.06) | .60 | 0.11 (0.07) | .12 | .42 |
Hyperuricemia | Full | −0.10 (0.43) | .82 | −0.40 (0.60) | .50 | .79 |
Time × Hyperuricemia | Full | 0.03 (0.06) | .64 | 0.10 (0.07) | .13 | .41 |
Buschke total recall | ||||||
Hyperuricemia | Min | 2.92 (1.61) | .07 | 1.80 (1.86) | .33 | .78 |
Time × Hyperuricemia | Min | −0.30 (0.18) | .11 | −0.31 (0.21) | .14 | .96 |
Hyperuricemia | Full | 2.68 (1.62) | .11 | 1.32 (1.88) | .48 | .85 |
Time × Hyperuricemia | Full | −0.29 (0.18) | .12 | −0.33 (0.20) | .12 | .89 |
Abbreviations: MMSE, Mini-Mental State Examination; Trails B, Trail-Making Test B
“Hyperuricemia” term represents the association between hyperuricemia and cognitive test performance at baseline. “Time × Hyperuricemia” term represents the association between hyperuricemia on the rate of change in cognitive test performance.
Hyperuricemia was defined as SUA ≥ 6.8 mg/dl for men and SUA ≥ 6.0 mg/dl for women.
Minimal models (Min): Adjusted for baseline age, time2, and education.
Full models (Full): Added adjustment for BMI, smoking, daily alcohol intake, exercise 3 or more times per week, hypertension, diabetes, stroke, antihyperuricemic medication use, and lipid-lowering medication use.
q-value < 0.05