FIGURE 1.

Experimental design. Animals were administered 4 mg/kg DFP (s.c.) immediately followed by 2 mg/kg ATS (i.m.) and 25 mg/kg 2-PAM (i.m.) and either developed continuous convulsive seizures (stage 3-5) or no continuous convulsive seizures. Animals were administered midazolam after animals had 20-min convulsive seizures (around 30-min post DFP), one hour or two hours post DFP to generate various durations of convulsive seizures (CS). Animals without continuous convulsive seizures were given midazolam one hour after DFP. Animals were terminated 8 days post DFP. CS, convulsive seizure, DFP, diisopropylfluorophosphate, ATS, atropine sulfate, 2-PAM, 2-pyridoxime.