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. 2021 Oct 15;15:757482. doi: 10.3389/fncel.2021.757482

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Copyright © 2021 Van Hoecke, Van Cauwenberghe, Dominko, Van Imschoot, Van Wonterghem, Castelein, Xie, Claeys, Vandendriessche, Kremer, Borghgraef, De Rycke, Hecimovic and Vandenbroucke.

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Increased cytokine and chemokine levels in the choroid plexus and CSF of NPC1^–/– mice. (A) qRT-PCR analysis of choroid plexus isolated from NPC1^+/+ (n = 11; black) and NPC1^–/– (n = 13; white) of 7 and 9 weeks old mice. Results are represented relative to the NPC1^+/+ condition. (B) Bioplex analysis of protein levels in CSF from NPC1^+/+ (black) and NPC1^–/– (white) mice (n = 5). Data are shown as mean ± SEM. Statistical analyses on datasets were performed by Mann–Whitney test. Asterisks indicate statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: non-significant). ND: not detected.