REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-Spike	GeneTex	Cat# GTX632604; RRID:AB_2864418
anti-IFIT1	Cell Signaling	Cat# 14769; RRID:AB_2783869
anti-ISG15	Cell Signaling	Cat# 2758; RRID:AB_2126200
anti-Viperin	Cell Signaling	Cat# 13996; RRID:AB_2734772
anti-STAT1	Cell Signaling	CAt# 9172; RRID:AB_2198300
anti-Vinculin	Cell Signaling	Cat# 18799; RRID:AB_2714181
anti-HIF-1a	Cell Signaling	Cat# 3716; RRID:AB_2116962
anti-LDHA	Cell Signaling	Cat# 2012; RRID:AB_2137173
anti-PKM2	Cell Signaling	Cat# 3198; RRID:AB_2252325
anti-p-PKM2	Cell Signaling	Cat# 3827; RRID:AB_1950369
anti-NOS2	R&D Systems	Cat# MAB9502; RRID:AB_2152874
anti-NS1	Santa Cruz	Cat# sc-130568; RRID:AB_2011757
anti-RCC1	Cell Signaling	Cat# 3589; RRID:AB_2269600
Bacterial and virus strains
Influenza A/PR/8/34 (H1N1)	Charles River	10100374
SARS-CoV-2 strain #291.3 FR-4286	Prof. George Koch	x
Chemicals, peptides, and recombinant proteins
L(+)-Lactic acid solution	Fluka BioChemika	69773
Lipofectamine RNAiMax	Invitrogen	12778-150
Critical commercial assays
BCA protein assay kit	Thermo Scientific	23225
High Pure RNA Isolation Kit	LifeScience	11828665001
Thermo ScientificTMPierceTMLDH Cytotoxicity Assay Kit	Fischer Scientific	P188953
Nuclear Extraction Kit	Active Motif	40010
QUANTI-Blue	InvivoGen	Rep-qlc1
Experimental models: cell lines
A549 cells
A549-Dual reporter cell line	InvivoGen	A549d-nfis
HEK-BlueTMIFN-α/β cells	InvivoGen	Hkb-ifnab
Oligonucleotides
SiLDHA	Santa Cruz biotechnology	Sc-43893
SiCtrl	Santa Cruz biotechnology	Sc-37007
Software and algorithms
Prism	Graph Pad	9
Other
Airway Epithelial Cells Basal Medium	PromoCell	C-21260
Airway Epithelial Cell Growth Medium Supplement	PromoCell	C-21260
Penicillin/Streptomycin	Gibco	10378
Bovine type I collagen solution	Sigma-Aldrich	804592
6,5 mm Transwell membranes	Corning	3470
DMEM-low glycose	Sigma-Aldrich	D5921
Hydrocortisone	StemCell	07925
Heparin	StemCell	07980
Pneumacult ALI medium kit	StemCell	5001
ALI medium supplement	StemCell	5001