Table 1.
Target expression in human, cynomolgus monkey and rat tissues
| tissue (n = 3) | human |
cynomolgus monkey |
rat |
|||
|---|---|---|---|---|---|---|
| pAb1 | pAb2 | pAb1 | pAb2 | pAb1 | pAb2 | |
| Adrenal | C* | - | C | - | - | - |
| Bone marrow | - | - | - | - | ScC | - |
| Breast | - | - | - | - | NF | - |
| Cerebellum | CB, N | CB, N | WM, GM, N, CB | GM, WM, CB, N | WM, GM, CB, N | CB |
| Cerebral cortex | GM, WM, N | GM, WM, N | WM, GM, N | GM, WM, N | GM, WM, N | GM, WM |
| Colon | MP | - | - | MP | MP | - |
| Heart | - | - | - | - | - | - |
| Ileum | - | - | MP | MP | - | - |
| Kidney | - | - | - | - | - | - |
| Liver | - | - | - | - | - | - |
| Lung | - | - | - | - | PM* | - |
| Lymph node | - | - | - | SC* | - | - |
| Ovary | - | - | - | - | - | - |
| Parotid | - | - | NF | - | - | - |
| Peripheral nerve | NF | NF | NF | NF | NF | NF |
| Pituitary | PN | PN* | PN* | PN | PN, PI** | - |
| Prostate | - | - | - | - | - | - |
| Skeletal muscle | - | - | - | - | - | - |
| Skin | BC* | - | NF | - | NF | - |
| Spinal cord | - | GM* | GM, WM | GM | GM | - |
| Spleen | RP | RP* | RP | - | - | - |
| Tonsil | - | - | - | - | N/A | N/A |
| Testis | - | - | - | - | - | - |
| Uterus (endometrium) | - | - | - | - | - | - |
pAb1- polyclonal anti-alpha-synuclein antibody 1 (ab6162 from Abcam); pAb2- polyclonal anti-alpha-synuclein antibody 2 (AB5038 from Millipore); “-“ – No positive immunostaining; C-chromaffin cells; GM-Grey Matter; WM-white matter; GC- Granule cells; ML-Molecular layer; N- nuclei; CB-Neuronal cell bodies; ScC- Scattered cells; NF- Nerve fibers; MP-Myenteric and submucosal plexi; LP: Lamina propria; PM-Pulmonary alveolar macrophage; SC-Sinus cells; PN-Pars nervosa; PI: Pars intermedia; BC: Basal cells (epidermal); RP-Red pulp; N/A- Not available.
*Staining in one donor only.
** Staining in one donor only, PN and PI not present in tissue sample from the other two donors.