Table 3.
Plasma PK parameters after single dose IV administration in cynomolgus monkey
| Dose (mg/kg) | AUC0-inf (h·µg/mL) |
Tmax (h) |
Cmax (µg/mL) | T½ (h) |
Vz (mL/kg) |
Cl (mL/h/kg) |
n |
|---|---|---|---|---|---|---|---|
| 1 | 5,230 | 0.75 | 28.8 | 252 | 69.9 | 0.193 | 2 |
| 3 | 19,100 | 0.83 | 72.2 | 354 | 79.9 | 0.158 | 3 |
| 10 | 60,700 | 0.67 | 237 | 308 | 72.2 | 0.166 | 3 |
| 30 | 189,000 | 0.50 | 733 | 345 | 79.8 | 0.161 | 3 |
AUC0-inf: area under the concentration-time curve from hour 0 to infinity; Tmax: time at maximum concentration; Cmax: maximum observed concentration, T½: terminal half-life, Vz: volume of distribution; Cl: clearance.