Table 7.

Predose concentrations of alpha-synuclein determined in cynomolgus monkeys.^a.

Alpha-synuclein	Sex	No. of animals	In plasma (ng/mL)		In CSF (ng/mL)
			Mean ± SD	Range (min-max)	Mean ± SD	Range (min-max)
Total	Males	16	23.3 ± 8.23	13.3–44.2	0.358 ± 0.560	0.101–1.90
	Females	16	37.2 ± 18.2	11.6–76.3	0.164 ± 0.142	0.080–0.666
Free	Males	16	29.6 ± 9.81	17.6–50.9	0.380 ± 0.534	0.139–2.08
	Females	16	38.8 ± 19.9	12.9–84.1	0.229 ± 0.216	0.0928–1.01

^aMeasured in study with 0, 30, 100 and 300 mg/kg LuAF82422.