Table 3.
Altered common pathways in MSC, PreA and MA adipogenesis stages in diabetic obese patients (ODs) by DMCs enrichment pathway analysis
| Go term | Gene number in OD-MSC (p-value) |
Gene number in OD-PreA (p-value) |
Gene number in OD-MA (p-value) |
|---|---|---|---|
| biological adhesion | 30(0.00002) | 114(0.0003) | 23(0.012) |
| negative regulation of macromolecule biosynthetic process | 17(0.03) | 93(0.0003) | 19(0.014) |
| regulation of apoptosis | 25(0.01) | 123(0.002) | 25(0.015) |
| regulation of cell death | 25(0.01) | 126(0.001) | 25(0.018) |
| regulation of programmed cell death | 25(0.01) | 124(0.002) | 25(0.017) |
| cell-cell adhesion | 14(0.001) | 46(0.016) | |
| haemopoiesis | 10(0.02) | 47(0.0004) | |
| haemopoietic or lymphoid organ development | 12(0.007) | 50(0.0006) | |
| homophilic cell adhesion | 9(0.002) | 27(0.005) | |
| immune system development | 12(0.01) | 50(0.002) | |
| phosphorylation | 24(0.01) | 140(1.73E-06) | |
| protein amino acid phosphorylation | 21(0.01) | 122(8.98E-07) | |
| regulation of small GTPase mediated signal transduction | 10(0.03) | 55(1.03E-05) | |
| cell-cell signalling | 106(2.30E-05) | 19(0.033) | |
| embryonic morphogenesis | 61(6.28E-05) | 13(0.012) | |
| epithelial tube morphogenesis | 14(0.04) | 5(0.036) | |
| epithelium development | 37(0.04) | 11(0.010) | |
| forebrain development | 31(0.003) | 10(0.002) | |
| induction of apoptosis | 50(0.03) | 12(0.038) | |
| morphogenesis of an epithelium | 25(0.0006) | 8(0.002) | |
| negative regulation of biosynthetic process | 101(4.09E-05) | 19(0.022) | |
| negative regulation of nitrogen compound metabolic process | 87(0.0007) | 17(0.034) | |
| negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 86(0.0007) | 17(0.031) | |
| negative regulation of RNA metabolic process | 62(0.002) | 13(0.039) | |
| positive regulation of gene expression | 91(0.004) | 19(0.025) | |
| positive regulation of macromolecule metabolic process | 138(0.0001) | 25(0.031) | |
| positive regulation of nitrogen compound metabolic process | 105(0.0006) | 21(0.018) | |
| positive regulation of transcription | 89(0.004) | 18(0.036) | |
| positive regulation of transcription from RNA polymerase II promoter | 59(0.01) | 15(0.010) | |
| regulation of carbohydrate catabolic process | 7(0.007) | 3(0.035) | |
| regulation of carbohydrate metabolic process | 11(0.01) | 4(0.036) | |
| regulation of cellular carbohydrate catabolic process | 7(0.007) | 3(0.035) | |
| regulation of transcription from RNA polymerase II promoter | 112(0.002) | 25(0.004) | |
| tissue morphogenesis | 34(0.007) | 9(0.0019) | |
| tube development | 40(0.006) | 10(0.022) | |
| tube morphogenesis | 24(0.02) | 7(0.032) | |
| anterior/posterior pattern formation | 7(0.04) | 7(0.047) | |
| cell adhesion | 30(2.35E-05) | 23(0.012) | |
| negative regulation of cellular biosynthetic process | 17(0.04) | 19(0.018) | |
| negative regulation of transcription | 15(0.03) | 17(0.012) |
*yellow = low enrichment; green = high enrichment; DMC: differential methylation CpG sites; MSC: mesenchymal stem cell; PreA: preadipocyte; MA: mature adipocyte.