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. Author manuscript; available in PMC: 2022 Jun 25.
Published in final edited form as: Biochem J. 2021 Jun 25;478(12):2385–2397. doi: 10.1042/BCJ20210158

Fig 1).

Fig 1)

A) Symbolic drawings of the carbohydrate structures of GAS (GAC), polyrhamnose backbone (pRha) in GAVS and M1_dgacI, GCS (GCC), GGS (GGC) and S. mutans (SCC). For simplicity, the reported glycerol phosphate of occasionally present on the GAC and SCC side chains have been omitted. Repeat units are marked with brackets. The pRha backbone with alternating (α1->2) and (α1->3) linkages, whilst the α1->2 Rha being decorated with a β1->3 side chain is a commonality among all PlyC susceptible strains. B) PlyC lysis of streptococcal pathogens. Group A and Group C Streptococci serotypes are susceptible to PlyC-mediated lysis. Group G Streptococci show limited susceptibility and S. mutans is resistant to PlyC lysis. Three SDSE isolates that produce the GAC instead of GGC (SDSE_gac) are susceptible to PlyC treatment. C) Bottom and top view onto WT PlyCB octameric structure with the GlyH and EAD domains omitted (4f78.pdb).