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. 2021 Oct 15;11:745719. doi: 10.3389/fonc.2021.745719

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Copyright © 2021 Lv, Wang, Zhao, Tan, Xiong, Yi, He, Ren, Wu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the association between m6A regulators and tumor microenvironment in a clinical cohort. (A) Expression of m6A regulators in high-risk group and low-risk group. (B) Expression of the 6 m6A-related lncRNAs in our clinical validation cohort. (C) The expression levels of METTL3 were significantly increased and METTL14 were significantly decreased in the high-risk patients than those in the low-risk patients of the clinical validation cohort. (D) Abundant M2 macrophage infiltration and co-expression of M2 macrophage marker CD206 and METTL14 was found in high-risk patients of the clinical validation cohort. *P < 0.05, **P < 0.01, ***P < 0.001. ns, no significance.