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. 2021 Oct 15;8:727412. doi: 10.3389/fmed.2021.727412

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Copyright © 2021 Lushnikova, Bohr, Wickbom, Münch, Sjöberg, Hultgren, Wirén and Hultgren Hörnquist.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentrations in pg/mg protein of all 15 analytes that were significantly altered in protein lysates from colonic biopsies from patients with active lymphocytic colitis (LC) and LC in histological remission (HR), active collagenous colitis (CC) and CC in HR, as well as active ulcerative colitis (UC) and UC in remission compared to controls. (A) BTLA, (B) CTLA-4, (C) IDO, (D) PD-1, (E) PD-L1, (F) PD-L2, (G) TIM-3, (H) 4-1BB, (I) APRIL, (J) BAFF, (K) CD27, (L) CD28, (M) MICB, (N) CD80, (O) IL-2Rα. Each point represents one patient, and the median is shown as a horizontal line. Q-values obtained from performing the original false-discovery rate method of Benjamini–Hochberg are shown as ^*q < 0.05, ^**q < 0.01, ^***q < 0.001, ^****q < 0.0001.