Table 5.
Summary of changes in all analytes in serum and in biopsies from patients with lymphocytic colitis (LC) or collagenous colitis (CC) with active disease and in histological remission (HR).
| Serum | Protein lysates from colonic biopsies | |||||||
|---|---|---|---|---|---|---|---|---|
| Analyte | LC active vs. ctrls | CC active vs. ctrls | LC active vs. ctrls | LC-HR vs. ctrls | LC-HR vs. LC active | CC active vs. ctrls | CC-HR vs. ctrls | CC-HR vs. CC active |
| Inhibitory | ||||||||
| BTLA | ▽1 | =3 | ▽ | ▽ | (▽)2 | (△) | (▽) | ▽ |
| CTLA-4 | N/A | N/A | (△) | (▽) | ▽ | ▲ aq=0.0223, bq=0.0178 |
▽ | ▼ q=0.0185 |
| E-cadherin | ▽ | ▽ | (▽)a | ▽a | ▽ | ▽a | ▽ | ▽ |
| IDO | ▼ q=0.0063 |
▼ q=0.0430 |
▽ | ▽ | ▽ | ▽ | ▼b
q=0.0493 |
▼ q=0.0493 |
| LAG-3 | ▽ | △ | ▽ | ▽ | ▽ | ▽ | ▽ | ▽ |
| PD-1 | ▼ q=0.0012 |
▽ | (△) | (▽) | ▽ | ▲ aq=0.0207, bq=0.0089 |
(▽) | ▼q=0.0189 |
| PD-L1 | N/A | N/A | (▽) | (▽) | (△) | ▲b
q=0.0204 |
(▽) | (▽) |
| PD-L2 | ▽ | (▽) | ▲ q=0.0090 |
△ | (▽) | ▲ aq=0.0297, bq=0.0327 |
▲ q=0.009 |
(△) |
| TIM-3 | ▼ q=0.0121 |
▼ q=0.0121 |
▼a
q=0.0072 |
▼a
q=0.0022 |
▽ | ▽ | ▼a q=0.0022 | ▽ |
| (Co)-stimulatory | ||||||||
| 4-1BB | ▼ q=0.0106 |
▽ | ▲a
q=0.0441 |
▽a | ▽ | ▲ aq=0.0025, bq=0.0047 |
▽ | ▼ q=0.0047 |
| 4-1BBL | ▲ q=0.0160 |
△ | (△) | (△) | (△) | (△) | △ | △ |
| APRIL | (▽) | (▽) | =a | (▽)a | (▽) |
▲b q=0.0029 |
(▽)a | ▽ |
| BAFF | (▽) | (▽) | △ | ▽ | ▽ |
▲b q=0.0326 |
▽ | ▽ |
| CD27 | ▼ q=0.0004 |
▼ q=0.0028 |
▼a
q=0.0266 |
▽ | △ | ▽ | ▼aq=0.0130, bq=0.0325 | ▼q=0.0353 |
| CD28 | N/A | N/A | ▽ | ▼a
q=0.0426 |
▽ | ▽a | ▽ | ▽ |
| CD40L | (▽) | (▽) | △ | (▽) | ▽ | (▽) | △ | △ |
| Galectin-3 | (△) | (△) | △ | (▽) | ▽ | △ | ▽ | ▽ |
| GITR | N/A | N/A | ▽ | ▽ | (▽) | ▽ | ▽ | ▽ |
| MICA | △ | = | (△) | (▽)a | (▽) | (▽) | △ | △ |
| MICB | (▽) | (▽) | △ | △ | (△) | ▽ | △ | △ |
| Both | ||||||||
| CD80 | ▼ q=0.0083 |
▼ q=0.0182 |
▽ | ▽ | ▽ | ▽ | ▽ | ▽ |
| HVEM | N/A | N/A | (▽) | ▽b | (▽) | (▽) | ▽ | ▽ |
| IL-2Rα | △ | ▲ q=0.0018 |
△ | (▽) | ▽ | ▲ aq=0.0021, bq=0.0001 |
(△) | ▽ |
Downward arrows (▽▼) indicate a decrease, upward arrows (△▲) indicate an increase in the analyte compared to non-inflamed controls. Filled arrowheads (▲▼) indicate a statistically significant finding in that group, empty arrows (▽△) denote non-significant findings.
Brackets(()) indicate that the difference was subtle.
The equals sign (=) denotes that the medians of those groups were equal.
denotes a comparison to controls;
denotes a comparison to diarrhea controls. Unless otherwise stated, a comparison to controls refers to both control groups. N/A means that the analyte failed to meet inclusion criteria (defined as at least 66% of samples in at least one patient group being above the detection limit of the assay) and were thus excluded from analysis. Q-values obtained from performing the original false-discovery rate method of Benjamini–Hochberg are shown.