Table 6.

Summary of changes in all analytes in biopsies from patients with ulcerative colitis (UC) with active disease and in remission, compared with control groups and patients with lymphocytic colitis in histological remission (LC-HR) as well as patients with collagenous colitis in histological remission (CC-HR).

Analyte	UC active vs. CC active	UC active vs. LC active	UC active vs. ctrls	UC rem vs. CC rem	UC rem vs. LC rem	UC rem vs. ctrls	UC rem vs. UC active
Inhibitory
BTLA	Δ1	Δ	Δ	Δ	Δ	▽	▽
CTLA-4	(▽)2	Δ	▲ aq=0.0412, bq=0.0200	(▽)	(▽)	▽	▼ q=0.0039
E-cadherin	▽	▽	▽	△	△	△	△
IDO	▽	△	▽	▽	▽	▼ aq=0.0493, bq=0.0068	▽
LAG-3	(▽)	△	▽	(△)	(△)	▽	▽
PD-1	(▽)	△	▲b q=0.0189	(Δ)	(Δ)	(▽) a	▼ q=0.0189
PD-L1	(▽)	(△)	(▽)	(▽)	(▽)	(▽)	(▽)
PD-L2	(▽)	(▽)	▲ aq=0.0090, bq=0.0090	▽	▽	△	▽
TIM-3	▽	△	▽	△	△	▼a q=0.0075	▽
(Co)-stimulatory
4-1BB	▽	(△)	▲ aq=0.0146, bq=0.0206	(△)	(▽)	▽	▼ q=0.0047
4-1BBL	▽	▽	(▽)	▽	▽	(Δ)a	(△)
APRIL	△	△	▲b q < 0.0001	△	△	△	▽
BAFF	△	△	▲ aq=0.0148, bq=0.0031	△	△	△	▼q=0.0326
CD27	▽	△	▽	▲ q=0.0328	△	▽	△
CD28	△	△	(▽) a	(△)	△	▽	▽
CD40L	▽	▽	▽	▽	▽	▽	(▽)
Galectin-3	▽	▽	△a	△	△	△	△
GITR	(△)	△	(▽)	▽	(▽)	▽	▽
MICA	(△)	▽	▽a	▽	(▽)	(▽) a	(△)
MICB	▽	▽	▼b q=0.0156	▽	▽	▽	△
Both
CD80	△	△	▽a	▽	△	▼a q=0.0439	▼ q=0.0439
HVEM	△	△	△	△	△	△	(△)
IL-2Rα	△	△	▲ aq=0.0236, bq=0.0021	▽	△	(▽) a	▼q=0.0236

¹Downward arrows (▽▼) indicate a decrease, upward arrows (△▲) indicate an increase in the analyte compared to non-inflamed controls. Filled arrowheads (▲▼) indicate a statistically significant finding in that group, empty arrows (▽△) denote non-significant findings.

²Brackets(()) indicate that the difference was subtle.

^adenotes a comparison to controls;

^bdenotes a comparison to diarrhea controls. Unless otherwise stated, a comparison to controls refers to both control groups.

Q-values obtained from performing the original false-discovery rate method of Benjamini–Hochberg are shown.