Table 1. Population-based therapeutic efficacy of albendazole against soil-transmitted helminth infections in three study sites.
The population-based therapeutic efficacy is expressed as the egg reduction rate, ERRP, defined as the reduction in the arithmetic mean fecal egg count (FEC) following administration of a single 400 mg oral dose of albendazole (see Eq (1)). The FECs were based on duplicate Kato-Katz thick smear. Ntot represents the total number of participants screened for STH infection; N+ the number of participants identified as infected at baseline by any of the four diagnostics (duplicate Kato-Katz thick smear, Mini-FLOTAC, FECPAKG2 and qPCR) and, NKK+ the number of participants infected at baseline by duplicate Kato-Katz thick smear. The 95% confidence intervals (CIs) were calculated using a non-parametric block bootstrap approach [23].
| Study site | Ascaris lumbricoides | Trichuris trichiura | Hookworm | |||
|---|---|---|---|---|---|---|
| N KK+ /N + |
ERRP (%) (95% CI) |
N KK+ /N + |
ERRP (%) (95% CI) |
N KK+ /N + |
ERRP (%) (95% CI) |
|
| Ethiopia (Ntot = 161) |
121/137 | 99.9 (99.8;100) |
86/106 | 48.1 (33.8; 63.4) |
67/90 | 96.3 (92.1; 98.6) |
| Lao PDR (Ntot = 239) |
97/111 | 99.2 (97.9; 99.9) |
92/105 | 40.5 (4.6; 40.0) |
215/228 | 96.2 (93.9; 97.8) |
| Pemba Island (Ntot = 245) |
148/193 | 96.7 (92.1; 99.6) |
245/245 | -4.9 (-22.3; 12.3) |
92/139 | 83.6 (74.2; 90.5) |