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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Genet. 2021 Jun 17;53(7):972–981. doi: 10.1038/s41588-021-00879-y

Extended Data Fig. 8. Lipid-disease pleiotropy from lipid-guided PheWAS in either eMERGE or UKB.

Extended Data Fig. 8

Circos plot indicates Bonferroni-significant SNPs in either cohort (eMERGE or UKB) from lipid-guided PheWAS (two-sided logistic regression). Outer track, the number of SNPs detected in either cohort; inner track, significant ICD codes per disease category. Links, SNPs connecting lipids (in salmon) to diseases (in blue); link thickness, # SNPs; link color, chromosome. Due to large number of SNP associations involved, this plot does not show associations (links) in the HLA region (chromosome 6).