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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Genet. 2021 Jun 17;53(7):972–981. doi: 10.1038/s41588-021-00879-y

Figure 2 |. Replication of lipid-associated genes across four cohorts from lipid TWAS.

Figure 2 |

The size of the points indicates the extent of replication for novel (fill) and previously reported (no-fill) genes across the four cohorts (eMERGE, GERA, GLGC, UKB) for a lipid-tissue pair. The colors represent the five tissues: adipose subcutaneous (AS), adipose visceral omentum (AV), liver (LV), whole blood (WB), and small intestine (SI). The shape of each point represents the four lipid traits (circles for HDL-C, squares for LDL-C, upward triangles for total cholesterol, and downward triangle for triglycerides). The right-hand side plot is a blown-up version of part of the left-hand side plot (up to an upper −log(P) threshold of 125) but for novel genes only. The solid red line corresponds to the Bonferroni-significance threshold.