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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Genet. 2021 Jun 17;53(7):972–981. doi: 10.1038/s41588-021-00879-y

Figure 4 |. Lipid-disease pleiotropy from Xpress-PheWAS and colocalization in either eMERGE or UKB.

Figure 4 |

Circos plots indicate Bonferroni-significant genes from lipid TWAS and Xpress-PheWAS in eMERGE or UKB. We have listed the genes with no LD contamination for both lipids and diseases (i.e. coloc P[H3] < 0.5). Furthermore, these genes also have P[H4] > 0.01 from Xpress-PheWAS. Outer track, number of genes; inner track, number of genes detected in either cohort; links, genes connecting lipids (in salmon) to diseases (in blue); link thickness, number of genes; link color, chromosome. On the right-hand side, we have delineated the list of the ICD-9 or ICD-10 codes corresponding to the disease categories, along with the genes associated with each disease category.