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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Genet. 2021 Jun 17;53(7):972–981. doi: 10.1038/s41588-021-00879-y

Figure 5 |. Concordant/discordant pleiotropy for SNPs that replicate in both eMERGE and UKB for the same lipids/diseases.

Figure 5 |

Left-hand side y-axis corresponds to lipids whereas right-hand side y-axis corresponds to the diseases. The x-axis corresponds to number of SNPs with net positive vs. negative effect sizes from lipid GWAS (two-sided linear regression) and lipid-guided PheWAS (two-sided logistic regression). We have also shown the chromosomes and base pair positions corresponding to the replicating SNPs on chromosomes 1, 6, 9 and 19. The disease-lipid associations corresponding to different chromosomes are indicated in different colors (blue, chr. 19; maroon, chr. 9; dark gray, chr. 6 HLA region; light gray, chr. 6 LPA region; orange, chr. 1).