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. Author manuscript; available in PMC: 2021 Dec 17.
Published in final edited form as: Nat Genet. 2021 Jun 17;53(7):972–981. doi: 10.1038/s41588-021-00879-y

Figure 6 |. Protective/risk effect genes from Xpress-PheWAS and colocalization that replicate in both eMERGE and UKB for the same lipids/diseases.

Figure 6 |

Replication is at the Bonferroni threshold with coloc P[H3] < 0.5 and P[H4] > 0.01. Lipids are indicated in red and diseases in blue. The letters in parentheses indicate the tissue in which either reduced/increased expression was observed. AS, adipose subcutaneous; AV, adipose visceral omentum; L, liver; WB, whole blood; SI, small intestine terminal ileum; MS, muscle skeletal; PR, prostate; BS, brain spinal cord cervical c-1; BP, brain putamen basal ganglia; SSE, skin sun exposed lower leg.