Table 4.
Adjusted healthcare costs of HER2 and endocrine therapy subgroups.
| Cost ratios | Total costs | 95% CI | OP costs | 95% CI | OP drug costs | 95% CI | IP costs | 95% CI | IP drug costs | 95% CI | ER costs | 95% CI |
| Intercept | 2,403.35∗ | 1,830.62 | 3,155.73 | 787.04∗ | 608.15 | 1,018.56 | 173.69∗ | 117.88 | 255.94 | 3,958.30∗ | 2,787.33 | 5,621.19 | 999.62∗ | 524.96 | 1,903.46 | 183.70∗ | 122.95 | 274.49 |
| Group | ||||||||||||
| BCF | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| MBC | ||||||||||||
| HER2 (+) ER(+) | 28.08∗ | 20.99–37.58 | 38.92∗ | 29.57–51.24 | 137.81∗ | 91.89–206.69 | 2.24∗ | 1.58–3.18 | 6.50∗ | 3.41–12.37 | 2.18∗ | 1.49–3.18 |
| HER2 (+) ER(−) | 21.57∗ | 15.01–31.00 | 26.58∗ | 18.88–37.44 | 85.51∗ | 51.63–141.62 | 3.84∗ | 2.52–5.85 | 10.05∗ | 4.63–21.80 | 5.70∗ | 3.55–9.16 |
| HER2 (−) ER(+) | 3.90∗ | 3.60–4.22 | 4.20∗ | 3.89–4.53 | 6.50∗ | 5.82–7.27 | 1.67∗ | 1.46–1.90 | 1.81∗ | 1.41–2.33 | 1.70∗ | 1.50–1.92 |
| HER2 (−) ER(−) | 1.69∗ | 1.55–1.83 | 1.76∗ | 1.63–1.91 | 1.94∗ | 1.72–2.18 | 1.07 | 0.90–1.25 | 1.26 | 0.93–1.71 | 1.23∗ | 1.08–1.41 |
| BC | 8.85∗ | 8.51–9.20 | 8.94∗ | 8.61–9.27 | 15.08∗ | 14.26–15.95 | 1.68∗ | 1.57–1.80 | 4.38∗ | 3.82–5.02 | 1.54∗ | 1.45–1.64 |
| Age | ||||||||||||
| 20–30 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| 31–40 | 1.10 | 0.90–1.33 | 1.07 | 0.89–1.28 | 1.11 | 0.84–1.46 | 1.52∗ | 1.18–1.94 | 1.78∗ | 1.13–2.80 | 1.33 | 0.99–1.80 |
| 41–50 | 1.11 | 0.92–1.34 | 1.19∗ | 0.99–1.42 | 1.24 | 0.95–1.62 | 1.29∗ | 1.01–1.64 | 1.36 | 0.88–2.12 | 1.33 | 0.99–1.77 |
| 51–60 | 1.32∗ | 1.09–1.59 | 1.45∗ | 1.21–1.73 | 1.65∗ | 1.26–2.16 | 1.26 | 0.99–1.60 | 1.30 | 0.83–2.02 | 1.45∗ | 1.08–1.93 |
| 61–70 | 1.65∗ | 1.36–2.01 | 1.76∗ | 1.46–2.11 | 2.14∗ | 1.63–2.81 | 1.36∗ | 1.07–1.74 | 1.15 | 0.73–1.81 | 2.00∗ | 1.49–2.69 |
| 71–80 | 1.99∗ | 1.62–2.44 | 1.73∗ | 1.42–2.09 | 2.11∗ | 1.58–2.81 | 1.83∗ | 1.41–2.37 | 1.49∗ | 0.93–2.40 | 2.43∗ | 1.79–3.30 |
| >=81 | 2.67∗ | 2.08–3.44 | 1.95∗ | 1.53–2.47 | 2.20∗ | 1.55–3.14 | 2.18∗ | 1.60–2.37 | 1.22 | 0.69–2.16 | 3.54∗ | 2.50–5.04 |
| Residential area | ||||||||||||
| Northern | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| Central | 0.46∗ | 0.38–0.56 | 0.92∗ | 0.76–1.10 | 0.90 | 0.68–1.19 | 0.47∗ | 0.36–0.61 | 0.27∗ | 0.16–0.43 | 0.49∗ | 0.37–0.65 |
| Southern | 0.50∗ | 0.41–0.62 | 1.01∗ | 0.84–1.22 | 0.98 | 0.74–1.30 | 0.47∗ | 0.36–0.61 | 0.22∗ | 0.14–0.37 | 0.55∗ | 0.42–0.74 |
| Eastern | 0.53∗ | 0.43–0.65 | 1.02∗ | 0.85–1.23 | 0.99 | 0.75–1.32 | 0.55∗ | 0.42–0.72 | 0.31∗ | 0.19–0.51 | 0.42∗ | 0.32–0.56 |
| CCI score | ||||||||||||
| CCI = 0 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
| CCI = 1 | 1.91∗ | 1.80–2.02 | 1.88∗ | 1.78–1.97 | 2.27∗ | 2.10–2.45 | 1.30∗ | 1.21–1.40 | 1.41∗ | 1.23–1.62 | 1.40∗ | 1.29–1.51 |
| CCI≥2 | 3.06∗ | 2.78–3.36 | 2.24∗ | 2.05–2.44 | 2.90∗ | 2.54–3.30 | 2.27∗ | 2.01–2.56 | 3.41∗ | 2.71–4.28 | 2.27∗ | 2.00–2.59 |