Table 3.
Correlation between molecular expression of oxidative stress genes with celluar hormones and mood scores in older adults with neurodepression disorders (n =40).
| Variables | m-RNA expression of oxidative stress genes in neurodepressed adults (n =40) | |||||||
|---|---|---|---|---|---|---|---|---|
| NO | iNOS | SOD2 | CAT | |||||
| Rs | P | Rs | P | Rs | P | Rs | P | |
| Cortisol | 0.75 | 0.01 | 0.35 | 0.01 | -0.43 | 0.001 | -0.31 | 0.01 |
| Serotonin | -0.28 | 0.01 | -0.18 | 0.01 | 0.15 | 0.001 | 0.21 | 0.01 |
| TMScore | 0.56 | 0.01 | 0.39 | 0.01 | 0.38 | 0.001 | 0.46 | 0.001 |
| Domains of POMScores | ||||||||
| Depression | 0.24 | 0.01 | 0.14 | 0.01 | 0.22 | 0.01 | 0.23 | 0.01 |
| Anger | 0.35 | 0.01 | 0.23 | 0.01 | 0.31 | 0.01 | 0.38 | 0.01 |
| Fatigue | 0.13 | 0.01 | 0.31 | 0.01 | 0.38 | 0.01 | 0.34 | 0.01 |
| Vigour | 0.58 | 0.01 | 0.14 | 0.01 | 0.53 | 0.01 | 0.36 | 0.01 |
| Tension | 0.49 | 0.01 | 0.18 | 0.01 | 0.29 | 0.01 | 0.58 | 0.01 |
Spearman's rho (rs) of miRNA relative expression levels vs. cellular oxidative stress genes, hormones activity, and mood score, 2-tailed significance (P), and number of subjects are presented. Correlations observed included hormonal markers and mood score frequency based on expression profiles of cellular oxidative stress genes. Nitric oxide (NO); endothelial nitric oxide synthase (iNOS); superoxide dismutase enzyme (SOD2); catalase enzyme (CAT); total mood score (TMscore); Profile of mood states (POMS).