Table 1.
Baseline demographic and clinical characteristics according to chronic RASI therapy at admission.
| OVERALL POPULATION (N = 3761) |
YEAR 2019 (N = 2014) |
YEAR 2020 (N = 1747) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| RASI (n = 2049) | No RASI (n = 1712) | P value | RASI (n = 1072) | No RASI (n = 942) | P value | RASI (n = 977) | No RASI 2020 (n = 770) | P value | |
| Age (median, IQR) | |||||||||
| Age > 75 year – n. (%) | 525 (25.6) | 344 (20.1) | <0.001 | 289 (27.0) | 196 (20.8) | 0.001 | 236 (24.2) | 148 (19.2) | 0.013 |
| Male gender – n. (%) | 1382 (67.4) | 1269 (74.1) | <0.001 | 734 (68.5) | 709 (75.3) | 0.001 | 648 (66.3) | 560 (72.7) | 0.004 |
| Hypertension- n (%) | 1853 (90.4) | 889 (51.9) | <0.001 | 955 (89.1) | 504 (53.5) | <0.001 | 898 (91.9) | 385 (50.0) | <0.001 |
| Hypercholesterolemia - n (%) | 1174 (57.3) | 774 (45.2) | <0.001 | 601 (56.1) | 422 (44.8) | <0.001 | 573 (58.6) | 352 (45.7) | <0.001 |
| Active Smoker – n (%) | 921 (44.9) | 837 (48.9) | 0.016 | 468 (43.7) | 455 (48.3) | 0.037 | 453 (46.4) | 382 (49.6) | 0.178 |
| Family History of CAD - n (%) | 365 (17.8) | 276 (16.1) | 0.169 | 205 (19.1) | 151 (16.0) | 0.069 | 160 (16.4) | 125 (16.2) | 0.936 |
| Previous STEMI- n (%) | 337 (16.4) | 151 (8.8) | <0.001 | 166 (15.5) | 84 (8.9) | <0.001 | 171 (17.5) | 67 (8.7) | <0.001 |
| Previous PCI – n (%) | 495 (24.2) | 201 (11.7) | <0.001 | 244 (22.8) | 108 (11.5) | <0.001 | 251 (25.7) | 93 (12.1) | <0.001 |
| Previous CABG - n (%) | 78 (3.8) | 38 (2.2) | 0.005 | 38 (3.5) | 24 (2.5) | 0.196 | 40 (4.1) | 14 (1.8) | 0.006 |
| Referral to Primary PCI Hospital | |||||||||
| Ambulance (from community) – n (%) |
880 (42.9) | 753 (44.0) | 0.303 | 462 (43.1) | 408 (43.3) | 0.149 | 418 (42.8) | 345 (44.8) | 0.699 |
| Time delays | |||||||||
| Ischemia time, median [25 - 75th] | |||||||||
| Total Ischemia time > 12 h – n (%) | 240 (11.7) | 266 (15.5) | 0.001 | 105 (9.8) | 137 (14.5) | 0.001 | 135 (13.8) | 129 (16.8) | 0.089 |
| Door-to-balloon time, median [25 - 75th] | |||||||||
| Door-to-balloon time >30 min (%)– n (%) | 1280 (62.5) | 1106 (64.6) | 0.176 | 650 (60.6) | 622 (66.0) | 0.012 | 630 (64.5) | 484 (62.9) | 0.483 |
| Clinical Presentation | |||||||||
| Anterior STEMI – n (%) | 956 (46.7) | 860 (50.2) | 0.029 | 505 (47.1) | 465 (49.4) | 0.312 | 451 (46.2) | 395 (51.3) | 0.033 |
| Out-of-hospital cardiac arrest – n (%) | 89 (4.3) | 80 (4.7) | 0.627 | 49 (4.6) | 41 (4.4) | 0.813 | 40 (4.1) | 39 (5.1) | 0.332 |
| Cardiogenic shock– n (%) | 179 (8.7) | 170 (9.9) | 0.209 | 86 (8.0) | 93 (9.9) | 0.145 | 93 (9.5) | 77 (10.0) | 0.736 |
| Rescue PCI for failed thrombolysis – n (%) | 194 (9.5) | 110 (6.4) | 0.001 | 103 (9.6) | 60 (6.4) | 0.008 | 91 (9.3) | 50 (6.5) | 0.032 |
*Mann-Whitney test.
CAD = Coronary Artery Disease; STEMI = ST-segment Elevation Myocardial Infarction; PCI = Percutaneous Coronary Intervention; CABG = Coronary Artery Bypass Graft;.