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SPP1-mediated EMT pathway and ERK1/2 pathway activation. Upregulating SPP1 promoted, while silencing SPP1 attenuated EMT. SPP1 overexpression significantly improved the expression levels of MAPK-p38 and ERK1/2 in the lentivirus-transfected LNCaP cell, and SPP1 knockdown significantly attenuated MAPK-p38 and ERK1/2 expression. (P values were computed by two-tailed unpaired Student's t-tests, ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.)
