Table 1.

Germline variants and the risk of pancreatic cancer

Gene	% of patients with pancreatic cancer	Increased Risk	Age 50+	Age 70
SEER USA population	–	1	0.05%	0.5%
Hereditary non-polyposis colorectal cancer (Lynch syndrome) genes	< 1	7–8	0.4%	4%
ATM	1–4	6	0.3%	3%
BRCA2	2–7	2–6	Up to 0.3%	Up to 3%
BRCA1	Up to 1	1–2.5	Up to 0.15%
PALB2	< 1	2.4	0.12%	1.2%
p16/CDKN2A	1–3	12–46	Up to 2.3%	Up to 23%
PRSS1	< 1	50–60	3%	30%
STK11	< 1	75–135	6.75%	Up to 67.5%
TP53	< 1	6–7	0.35%	Up to 3.5%

⁺Using the high end of the range of increased risk