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. 2021 Oct 29;12:6237. doi: 10.1038/s41467-021-26519-x

Fig. 7. αSYN and IFNγ induce toxic microglia.

Fig. 7

Culture media of microglia cells exposed to either IFNγ or αSYN elicit a significant loss of DA neurons (red) which is synergically increase when both treatments are combined. Data are the mean ± s.e.m from n = 4 independent experiments. Two-sided Kruskal–Wallis test is followed by the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli. ***p = 0.003 (control vs. +IFNγ/+Fibr), p = 0.009 (+IFNγ vs. +Fibr/+IFNγ) and *p = 0.03 (+Fibr vs. +Fibr/+IFNγ). Scale bar, 500 µm.