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. 2021 Oct 29;11:21297. doi: 10.1038/s41598-021-00851-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Network structure of the respiratory microbiota between patients with different severity levels of COVID-19. (A) Co-occurrence/exclusion networks for patients with mild, severe and fatal COVID-19. Each node represents a microbial group at ASV level and each edge an interaction (either co-occurrence or co-exclusion). Colors denote phylum identity. Number of samples used to construct the network (N), number of nodes, and number of edges are reported in the figure. (B) Spider chart of the topological metrics associated to each network.